• Turns out internet businesses are sustainable during pandemics. Why? Home Office DNA

      “In 1665, Cambridge University closed because of the plague. Issac Newton decided to work from home. He discovered calculus & the laws of motion.”

      We live in a truly remarkable moment. With the year 2020 and the COVID-19 outbreak employees all over the world are staying home for quarantine, trying their best to sustain the normal flow of life, which means continue working. And this is something new compared to all the previous infectious pandemics humanity has survived through — this time we have the Internet.

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    • Dobroshrift

        What one gets easily and for free can be a real struggle for others — these are the thoughts every letter of the «Dobroshrift» [Kindness Font] evolves. It was developed for the World Cerebral Palsy Day with the participation of children with this diagnosis. So we decided to take part in this charity action and changed the website logo till the end of the day.


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      • indibiome labs

          I would like to share main points of my Skolkovo application for Startup Village 2019 pitch.

          Indibiome labs


          image

          Project Executive Summary indicating current developments and basic goals of the Project


          Indibiome labs for kids are franchise network food labs providing safe environment where kids (13+) will learn how to analyse the food content and study influence of foods on health and will spread this knowledge through social networks, therefore educating other kids and adults in the field of healthy nutrition.


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        • Indibiome is the new black

            Indibiome is the new black, following the steps of electric and computer engineering industries, we are foreseeing indibiome design bureaus able to solve unmet needs in healthcare, agriculture, food production, industrial applications.

            Indibiome is discussed in my previous paper in Russian (link). Shortly indibiome is indigenous microbiome, like indigenous people, term is used below in the meaning «inherent to the media, localised and optimised for sustainable existence»).

            Microbes have always been there, however technologies allowing efficient microbes manipulation and accumulated genetic and experimental data on variety of microbial communities has been on the rise only last decade. Below is my concept of interdisciplinary «indibiome bureau» and you are most welcome to give feedback.
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          • Finally, rejuvenation is a thing


              Preface


              What is ageing? We can define ageing as a process of accumulation of the damage which is just a side-effect of normal metabolism. While researchers still poorly understand how metabolic processes cause damage accumulation, and how accumulated damage causes pathology, the damage itself – the structural difference between old tissue and young tissue – is categorized and understood pretty well. By repairing damage and restoring the previous undamaged – young – state of an organism, we can really rejuvenate it! It sounds very promising, and so it is. And for some types of damage (for example, for senescent cells) it is already proved to work!

              Today in our virtual studio, somewhere between cold, rainy Saint-Petersburg and warm, sunny Mountain View, we meet Aubrey de Grey, again! For those of you who are not familiar with him, here is a brief introduction.
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            • Laser that cuts inside the cornea: ReLEx procedure at the physical level

              • Translation
              The idea — to take and cut a lens in a transparent cornea — is not new. At first it was done manually, with a scalpel directly on the surface (difficult and very rough, with a sea of side effects). The first laser was used in 1979, then it was a pulsed infrared emitter with an effective pulse length of 4 nanoseconds.


              Step 1: creating a plasma bubble, in fact — a microburst. Step 2: expansion of the shock and heat waves. Step 3: cavitation bubble (plasma expansion). Step 4: the formation of a parallel slice at the expense of several adjacent laser focus points.

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            • Everything you always wanted to know about human memory (but were afraid to ask)

                Having a good memory is advantageous, even as people stay home amidst the pandemic. Our memories help us maintain an intellectual connection to the world, and keep us from mentally deteriorating.

                Today, we’re launching a new series of articles on memory enhancement, starting with a short overview of how our memory works and the basic training you can undergo to improve it.


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              • AdBlock has stolen the banner, but banners are not teeth — they will be back

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              • We implant an artificial lens (you will need it after 60 years)

                • Translation


                The lens in your eye can change its optical power: when you focus somewhere on the vision, this is what happens. Payback for the «moving parts of the mechanism» — wear with age. At about 40-45 years old, problems usually begin with age-related visual impairment; in 60-70 years, you need up to three pairs of different points. At the same time, the clarity of view is reduced due to the process of sclerosis and lens opacity — it is worth thinking about replacing the lens, until it becomes dim and becomes completely rigid.

                To date, the technology of replacing the lens is standardized and well developed. Potential risks are generally somewhat higher than with laser vision correction, but at present this type of surgery is performed even on transparent lenses with refractive purpose (when the patient does not like to wear glasses with thick glasses), that is, it is quite a “household” task for ophthalmology.
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              • Research in rejuvenation biotechnology – where are we now?



                  Certainly this event is an example of some of the people in our longevity community coming in and just taking over a little bit of somebody else's conference to talk about longevity… but really exposing the rest of the community to it. I'm finding that at every event I go to, I'd really love to have conference presentations where I get to talk about some interesting thing about the longevity industry, because there are a lot of really interesting things going on.

                  But every presentation turns out to be «hey, we exist, please notice us — because this is really, really important.» Everything that you guys think that you are doing in medicine is about to be up-ended, because suddenly we're going to be actually able to stop people from getting sick and incapacitated and debilitated in old age. This is happening right now, the first rejuvenation therapies exist. But nobody notices.
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                • Cataract: it is waiting for you personally (if you live, of course)

                  • Translation

                  This is a model of an intraocular multifocal lens from Carl Zeiss. The real size of such a lens is 11 millimeters, the diameter of the optical zone is 6 mm.

                  The cataract is, simplifying, age opacification and consolidation of a crystalline lens. According to the classical definition, we are talking about the turbidity of any type. First, something gets in the field of view, a general “fog” appears, you want to wipe dirty glasses, then you do not see the letters in the book, then you want to turn on the light brighter or, on the contrary, you hide from the bright light, and then wake up one fine morning and understand that you can not find slippers. And you see nothing at all — only the shadows. This process sometimes stretches for many years, but slippers are still lost. Mention of clouding that develops in the eyeball, there are still thousands of years before our era.

                  The treatment procedure has historically been very peculiar — reclination of a cloudy lens. The doctor took the patient with a very dense lens — to that dense stage that the patient is already blind. During the excavations of the settlements of ancient Greece and Rome, the tools used by doctors to remove cataracts were found — sharp needles that pierced the eye and lens, destroying its supporting apparatus. The lens could come off and, by virtue of its gravity, could also fall down from hitting the back of the head with a heavy stick several times. Sometimes the patient died during the emergency eye care, sometimes he had a concussion, and sometimes the lens fell off the ligaments and flew deep into the eye. The patient began to see again — he had a huge lump and vision of about +10 +15 diopters.

                  Now two news. The bad — people began to live to cataracts more often, and it is inevitable. Good — we have something better than sharp needles and a heavy stick.
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                • FAQ about laser correction ReLEx SMILE: yes, in Russia there is, but no, in Russia there isn’t

                  • Translation


                  — Are small-invasive laser vision correction operations done in Russia using the Small Incision Lenticule Extraction method?

                  Yes, about 10 years already. Every year, more and more at conferences of ophthalmologists, questions arise not at the level of “What is this?”, But at specific practical nuances of technology. VisuMax lasers exist in several clinics in Russia, but it is much less used under ReLEx SMILE than under femtoLASIK. Historically, it happened in Russia that this technology is little used in the central part and is actively used beyond the Urals.

                  — What is the story with licenses for specific operations?

                  Zeiss sells cones with licenses. A cone — a replacement part adjacent to the eye — is purchased with a license to use a laser procedure, usually in batches of 10 or 100 operations. For example, 10 cones and 10 licenses are received. Licenses are driven through the laser menu, and it allows you to use the appropriate cones for the appropriate program types. Licenses for SMILE separately, for femtoLASIK separately, for FLEX, rings and additional corrections are also separate licenses. Most manufacturers of femtosecond and some excimer lasers have a similar situation. Licenses for excimer operations are not needed, perhaps, except on models of about 5 years old and older.

                  — And you can not get such a license for SMILE?

                  Easily. Firstly, this module in the laser is as an expensive option, so the device itself without the SMILE option is cheaper. Secondly, if this option is available, then licenses to carry out the operation ReLEx SMILE can be acquired only after conducting 5–10 test runs on pig eyes, then performing at least 10 femtoLASIK operations on patients, then 50 FLEX operations, and only after that Buy a SMILE license for a specific surgeon.
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                • A couple more unobvious things that you might not be told before laser vision correction

                  • Translation

                  Today, without the «tin», as you asked

                  There is already a post about how the laser cuts by creating millions of cavitation bubbles in the cornea layer of the eye, and analyzing telemetry from the real operation in seconds with comments of the surgeon's actions.

                  Now FAQ about various related things


                  — If I look away while the laser is running, what will happen?

                  You simply will not work. In fact, immediately after anesthesia, the eye is pressed against a special pneumocapture. To blink at you too will not leave because of fixing (it is not long and not for long). The only moment where it is possible to seriously disrupt the course of the operation is to pull the head down strongly, pulling it out of the headrest by a serious willed effort. In this case, the operation will instantly stop. More precisely, it will stop even before the loss of capture (details below).

                  — How should an operating room be prepared?

                  In general — as a normal operating room, that is, a room with a clean area (air filtration, overpressure to prevent contamination from the outside after cleaning). It is important for the procedure that microparticles of dust flying in the air do not fall between the laser lens and the eye.
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                • Blood sugar and COVID-19

                    Novel pandemic is very new for science, often it takes years before scientists prove connection of risk factors and replicate their findings in experimental setups, but it is not the case to wait. I have been observing different facts about COVID-19 and propose “Hypothesis for connection between blood sugar levels and infection”. The only reason I do this now with so many controversies is that I genuinely believe it can save lives. Lives of my friends, and their relatives.

                    In the article below I summarise my knowledge on infection and immunity, back it up by links to COVID observations of doctors and scientific papers.
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                  • The Flight with a Dosimeter in the Pocket

                    image

                    The developer of personal dosimeters presented me with an interesting gift at one of Skolovo conferences in early 2011. It was a funny DO-RA gadget made in the form of an Easter egg and packed in a large cardboard box like a smartphone. Apparently, its designers new that their boss Viktor Vekselberg, chairman of the Skolkovo Foundation, was fond of Faberge eggs. They made a plastic copy of the famous Easter gift of the Russian Imperial Court.

                    I found a dusty box with the DO-RA gadget just before a business trip to the United Arab Emirates. The device had no battery and was connected to Apple smartphones via a standard audio jack. It is worth noting that, starting with the 7th iPhone model, the Apple Inc. no longer releases smartphones with an audio jack considering it an anachronism. However, the abandonment of the quite utilitarian interface such as audio jack coincided with the release of expensive Airpod earphones. Well, it's their business to earn money on all sorts of restrictions.
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