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The whole idea behind Prism is that by itself it's an application that lets users split web applications out of their browser and run them directly on their desktop.
As each web application uses the W3C standards, it's basically a web site you run in an individual window outside of the browser. The concept has similarities to Opera Platform SDK for devices and it should be able to work in any web browser as long as it can deal with the .webapp extensions.
In simple words you can "save" your Gmail page, and open it up later in an individual web browser window without the complete menus and tool bars. Advanced techniques involved with this are offline usages (you do want to be able to work on your mail draft when not connected), which add additional complexity.
Mozilla Labs играется с призмой