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Doctors suspected analyphylaxis from transfer of an allergy antibody in blood plasma that can react against allergens in rare cases
It is the clear plasma component of blood that contained the allergy antibody from a donor with a severe allergy to peanuts, tree nuts, shellfish and fish, the researchers said.
A pooled platelet transfusion suspended in about 200 mL of plasma from the atopic donor was inferred to be the source of the passively transferred IgE. There were no remaining donor blood products to test for specific IgE.
About 4.5 months after the patient’s allergic reactions, specific IgE to both salmon and peanut was undetectable (< 0.35 kU/L). When contacted with these results and to arrange follow-up about 6 months after his reactions, the patient’s family had already reintroduced salmon and peanuts to the patient’s diet, and he continues to eat an unrestricted diet including fish and nuts. Repeat skin testing was not performed because there was no longer a suspicion of allergy.
Passive transfer of IgE from blood products as a cause of food allergy is a rare mechanism of a common pediatric problem.
The prognosis of passively acquired IgE-mediated allergy from blood products is excellent, with resolution within a few months.
Есть таргетная терапия, уничтожающая B-лимфоциты (все вообще) - но она применяется только при лимфолейкозе или тяжелых аутоиммунных заболеваниях. rituximab, obinutuzumab. Использовать при пищевой аллергии - пушкой по воробьям. Чтобы против производящих конкретные антитела - такого нет.
Мальчик получил все аллергические реакции донора при переливании крови