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Interview with Stephanie Planque from Covalent Bioscience

Reading time 8 min
Views 86

What is ageing? We can define ageing as a process of accumulation of the damage which is just a side-effect of normal metabolism. While researchers still poorly understand how metabolic processes cause damage accumulation, and how accumulated damage causes pathology, the damage itself – the structural difference between old tissue and young tissue – is categorized and understood pretty well. By repairing damage and restoring the previous undamaged – young – state of an organism, we can really rejuvenate it! It sounds very promising, and so it is. And for some types of damage (for example, for senescent cells) it is already proved to work!

Today in our virtual studio, somewhere between cold, rainy Saint-Petersburg and warm, sunny Huston, we meet Stephanie Planque! For those of you who are not familiar with her, here is a brief introduction.

Stephanie Planque was awarded the PhD in 2009 by the University of Texas-Houston Medical School for her advances in applying electrophilic analogs of proteins to decipher the beneficial and harmful functional effects of catabodies. She then expanded her focus to vaccination and therapeutic catabody identification using proprietary electrophilic target analogs. Her work was published in 49 peer-reviewed scientific articles, she has numerous national/international conference presentations. She moved fulltime as a co-founder to Covalent Bioscience in 2018 to focus on rapidly translating their electrophilic vaccine/catabody technologies to clinical reality.

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Total votes 5: ↑4 and ↓1 +3
Comments 0

SHA-256 Reversing in Bitcoin Systems as a Neural Machine Translation Problem

Level of difficulty Medium
Reading time 15 min
Views 278

Bitcoin is a digital currency created in January 2009 due to the housing market crash. It is designed to have lower transaction fees than traditional online payment mechanisms. Each Bitcoin transaction is recorded in a public log, but the identities of buyers and sellers remain anonymous. While this privacy feature allows users to conduct transactions without being traced, it also facilitates the buying and selling goods and services without leaving a trail. Bitcoin is built on cryptographic evidence, avoiding weaknesses inherent in trust-based models.  Cryptography is critical to the Bitcoin system as it maintains data secrecy and prevents unauthorized spending from another user's wallet. Advancements in cryptography have led to the development of various hashing algorithms to secure sensitive data. The SHA-256 hash function is widely recognized as a robust and extensively used cornerstone. However, the reversibility of hash functions remains a critical issue in cybersecurity. In the following essay, we propose that one-way cryptography processes based on hash functions can be reversed using neural networks in machine translation. Assuming this hypothesis is true and considering some quantity algorithms to decrypt certain types of hash functions, we will highlight their effects on the Bitcoin system.

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Total votes 8: ↑8 and ↓0 +8
Comments 0

After sale IT support for American and Western Companies

Reading time 2 min
Views 73


After sale IT support for American and Western Companies 

Let’s have a case study. 

A Russian IT company sells software to a western country like say America. And you are working as an application developer on the support side. 

One day, there is a problem with the program, and the program has stopped working. 

You must contact the company now to inform them that the program is off-line. 


The way, the two cultures operate in a situation like this are very different and it will have everything to do with how easy your job goes for you.


Russia : “we have a problem”

“What is wrong?”

“I don’t know”

“When can it be fixed?”

“I don’t know”


USA: “i’m just giving you a real quick call to let you know that there is a problem with the program. 

I’ve already put my team on it and we will have it up and running shortly. 

I will let you know more by 3 o’clock today what is going on”

It’s not important how long you think it will take you, but I will always tell them a few hours from the time that you informed them of a problem.

I understand that you have no idea how deep the bug is and also whether it will affect any other systems.

But it is important to set a time window very close to when you inform them that you will bring them more information. 

This also works very well if you don’t know something that they ask you.


“What can we do to fix this problem?”


“I understand what you’re saying. I will look into it and get back to you in two hours.  By 1 PM today.”

in this case, it’s important that you: 

1. Take responsibility for yourself and your team.

   2. Communicate that you understand this responsibility.

   3. Gives strict timelines. (if it’s not possible, you can always say that there is a problem, but do it before the deadline.) 

    4. Use certain key language.

“ I understand you”

“ I understand what you were saying”

“ I wanted to inform you”

“ we are working on it right now”

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Total votes 2: ↑1 and ↓1 0
Comments 0

Dedoc: как автоматически извлечь из текстового документа всё и даже немного больше

Level of difficulty Medium
Reading time 11 min
Views 738

Привет, Хабр! 

Мы команда разработчиков Института Системного Программирования РАН, занимаемся Computer Vision в обработке электронных документов. Мы разработали open-source библиотеку dedoc, которая помогает разработчикам и дата-сайентистам в пару строк кода читать различные форматы текстовых документов и изображений с текстом, и далее приводить информацию к единой аккуратной структуре.

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Total votes 3: ↑3 and ↓0 +3
Comments 1

How to send messages over sockets and create your own messanging protocols in C++

Level of difficulty Medium
Reading time 28 min
Views 538

Network programming in C++ can be challenging. But even a greater challenge is to find educational content that will arm you with the knowledge on how to apply your networking skills in real applications.

In this article you can learn the basics of socket communication and many ways how you can design your internal messaging protocols.

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Total votes 2: ↑2 and ↓0 +2
Comments 2

How to Bypass reCaptcha in Selenium Automatically with Code Example

Level of difficulty Easy
Reading time 4 min
Views 184

I based my approach on an English manual that caught my eye just a couple of days ago, and I decided to test it (since it's written by a captcha recognition service that I use, why not - by the way, guys from 2captcha - I accept thanks in the form of green bills, if you're interested))))

I've made some tentative attempts at automation and encountered a frequently arising problem: reCaptcha recognition.

Of course, I understand that there are many guides, manuals, and articles written on this topic, but let's agree - it's interesting to describe one's own experience.

Thus, without getting too lengthy and boring about why Selenium is necessary, how important it is for automation, when it appeared and who invented it, let's get to the crux:

To solve the problem, we'll use a demo page kindly provided by reCaptcha itself - https://recaptcha-demo.appspot.com/recaptcha-v2-checkbox.php:

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Rating 0
Comments 0

Why x^0 = 1 visually

Reading time 3 min
Views 626

The traditional definition for the operation of exponentiation to a natural power (or a positive integer) had introduced approximately as follows:

Exponentiation is an arithmetic operation originally defined as the result of multiple multiplications a number by itself.

But the more precise formulation is still different:

Raising a number X to an integer power N is an arithmetic operation defined as the result of multiple [N by mod times] multiplications or divisions one by number X.

Let's figure it out under the cut! >>
Total votes 5: ↑5 and ↓0 +5
Comments 0

Crafting Enhanced Dropdown Interactions with Svelte: Constructing an Advanced Dropdown Component with Svelte

Level of difficulty Medium
Reading time 3 min
Views 172

In the realm of frontend development, the quest for enhancing user interaction remains a constant pursuit. Developers, inspired by innovation, often seek solutions to refine components for a seamless user experience. Today, we delve into the construction of an advanced dropdown component using Svelte — a framework known for its simplicity and effectiveness.

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Total votes 3: ↑3 and ↓0 +3
Comments 0

A short guide to UX writing and its role in UX design

Level of difficulty Medium
Reading time 5 min
Views 305

UX writing is an essential part of UX design, which plays a huge role in providing qualitative user experience. The job of a UX writer is to compose texts for a digital product, which can be of two types: microcopy (labels, buttons, notifications and other small notes) and macrocopy (larger texts like written content on pages, instructions, information sheets). UX writing helps users easily navigate through the product, perform various tasks and get all the necessary information.

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Rating 0
Comments 1

Your Name: Why it’s Important in American Sales and Marketing

Reading time 2 min
Views 552

This is one of the most important articles I’ve written. 

In this article, I’m going to dive deep into one of the largest differences between Russia and America pertaining to sales and marketing. 

1. You must use your name. 

2. You must have a personal approach. 

3. You must show that you are involved. 

4. You must show that you care about the needs and desires of the client. 

Recently, I was faced with an interesting problem. I was asked to call clients without making it personal. 

So let’s go back to when I was in America, living and working as a sales person. The company I work for, was very large, and had multiple branches around the Washington DC area. They had offices in three states. 

They put me through a sales training course. 

The biggest “take away” from the course….. 

You’re not selling the product/ 

you’re selling yourself. 

It's important to use your charisma and your genuine caring for the customer to win them over. Once they understand that you're actually trying to help them, then they will seriously consider the item you are telling them about. 

I also want to say, very clearly, that it's not a prideful approach. It should be a professional approach. You're responsible to tell the customer/ the client all the benefits of the item and how this item will help their business.

Everything above pertains to sales in America. So if you are approaching America as a sales manager this is how you should craft your approach. 

Now I've spoken to my colleague,

Kristina Pashnina and we have agreed upon some stark differences to the Russian sales climate. Here she will begin to tell you how the Russians see sales. 

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Total votes 1: ↑1 and ↓0 +1
Comments 4

Empowering Digital Artists: Building a Royalty-Enabled NFT Marketplace

Level of difficulty Easy
Reading time 5 min
Views 295

As NFTs spread across the world, users spent millions of dollars to buy digital assets to prove their uniqueness. Many creators and artists showcase their beautiful products, such as artworks, music, etc., in the NFT marketplace. What if a creator can profit from their work even after selling it to another business? This is where royalty comes in; it is a recent addition to the NFT space. Owing NFT royalties can benefit artists and creators from succeeding sales to the business. 

Once NFT royalties became a hot topic and gained popularity among artists and creators. Later, arguments were evolved to remove royalties that had swayed other NFT creators. DeGods, the popular Solana's NFT project, has moved its royalty model to 0%. However, creating a royalty-based NFT marketplace attracts many creators around the world. In this article, we will delve into the development process of NFT marketplace royalties and how it benefits enthusiastic artists from secondary sales. 

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Total votes 3: ↑3 and ↓0 +3
Comments 1

Exploring VALID/READY protocol, pipelines and experimenting with flow control using an HDL training tool

Level of difficulty Medium
Reading time 1 min
Views 468

Ссылка на русскую версию / link to Russian version

Understanding valid/ready protocol is extremely important for every microarchitect.

Valid/ready is one of the main protocols used to organise flow-control inside a logic block as well as on inter-block (SoC) level.

In the last lesson, we explored FIFO buffer using hdlgadgets - human-in-the-loop HDL training tool.

This time we will take two FIFO buffers (which form a pipeline with valid/ready handshakes) and will experiment with it by changing flow-control logic of the pipeline.

We will show that valid/ready is not only a mechanism for transferring data from one FIFO queue to another, but also a method for organizing various kinds of logical functionality between queues.

If you have not worked with valid/ready protocol before, you will be surprised how easy it is to achieve desired functionality of the design by simply writing couple of lines of Verilog code in the handshaking logic block between two FIFOs.

Read further and watch the video
Total votes 6: ↑6 and ↓0 +6
Comments 0

Game economy design of Premium games through the example of a 4X strategy on PC

Level of difficulty Medium
Reading time 9 min
Views 578

How to design an economy for your game? The answer to this question might require a series of lectures or articles. The fundamental difference in the approach is based, first of all, on monetization model: F2P or B2P. The second thing that defines the approach to developing an economy system is game genre. This article reviews the case of designing the game economy for a B2P (premium) game, which doesn’t involve earning on microtransactions.

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Total votes 1: ↑1 and ↓0 +1
Comments 0

Building an IT website, aimed at America and the West

Reading time 3 min
Views 690

My last article stirred up some definite comments and even questions about different things in business. I’m going to keep giving you as much information as I can so that you can continue to do business as IT professionals outside of Russia with other countries. 

How do you design a website that will be viewed in the west and appreciated by the people there?

What are the most important elements

for, America and other western markets?

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Total votes 1: ↑1 and ↓0 +1
Comments 8

Marketing your Mindset

Reading time 2 min
Views 381

Information shared below is exactly how I work with my IT professionals who are going to be participating in pre-sales to America. I tell them exactly this, and it helps prepare them to successfully sell the the United States companies.

As developers and IT companies, we must sell our software.

What can give you an edge in this very competitive market place?

Please, if you would allow me to let me explain why this is important and how this can make your company more successful. There’s a certain type of thinking that is conducive to working as a software developer. This is a very practical mindset, but it goes beyond that. If you have the mindset of direct thinking.

Here are examples:

I see the target a target and I don’t see obstacles

Вижу цель, не вижу препятствий

This is an example of the practical mindset, how is approaches the problem of development. It makes people who have this mindset, the best developers in the world.

Example of mindset:

Problem……………… find a solution………… No problem.

Notice how this looks exactly like a line of code?

This is well-known around the world in places where you would like to sell your software, the United States, Germany, Belgium, and the Middle East.

Countries where people have this mindset have the best developers.

now let’s talk about your competition:

Americans: during the center process, “find a solution” Americans are overly concerned about responsibility. This slows them down in the decision making process.

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Total votes 1: ↑0 and ↓1 -1
Comments 2

PostgreSQL 17: Part 2 or Commitfest 2023-09

Reading time 11 min
Views 683

We continue to follow the news of the PostgreSQL 17 development. Let's find out what the September commitfest brings to the table.

If you missed our July commitfest review, you can check it out here: 2023-07.

Removed the parameter old_snapshot_threshold
New parameter event_triggers
New functions to_bin and to_oct
New system view pg_wait_events
EXPLAIN: a JIT compilation time counter for tuple deforming
Planner: better estimate of the initial cost of the WindowAgg node
pg_constraint: NOT NULL constraints
Normalization of CALL, DEALLOCATE and two-phase commit control commands
unaccent: the target rule expressions now support values in quotation marks
Audit of connections without authentication
pg_stat_subscription: new column worker_type
The behaviour of pg_promote in case of unsuccessful switchover to a replica
Choosing the disk synchronization method in server utilities
pg_restore: optimization of parallel recovery of a large number of tables
pg_basebackup and pg_receivewal with the parameter dbname
Parameter names for a number of built-in functions
psql: \watch min_rows

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Total votes 3: ↑3 and ↓0 +3
Comments 2

How to Use Throw and Throws in Java

Level of difficulty Easy
Reading time 2 min
Views 612

Exception handling in Java is the most effective way to handle runtime errors occurring in the application. This is used to protect the abnormal flow of the execution of the application and continue the application in normal flow. This is the process of handling runtime errors such as ClassNotFoundException, IOException, etc. The throw and throws keywords are used to handle exceptions in Java.
In this topic, we will learn how to use throw and throws keywords in Java with examples.

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Total votes 3: ↑3 and ↓0 +3
Comments 0

The key to Sales Conversion of an American CEO or CFO

Reading time 1 min
Views 552

i’m writing this series articles to spearhead the new marketing campaign for into the American market. I will be covering a wide range of topics that will allow us to position the company in the proper way so that is excepted as a provider of High-quality software in America.

The key to converting an American CEO or CFO is the trigger point for the American business culture. The trigger point for America is responsibility.   This means in business you must be responsible. You also look for business partners that are responsible.  

But let’s take this into the newest more powerful view that we need to have now.  

The scene from the point of you of the CFO sitting at the head of the financial controls of a large hospital conglomerate. Put yourself in the mind of the CFO. What are they concerned about?  

As an American CFO they will be very concerned about whether they are being responsible in their job and responsible to the hospital, staff, shareholders, patients and the management above them. 

And this is how we get our foot in the door in this American niche market. If we present ourselves as offering something that “May” give an answer to specific problems that they know that they have, they must give us a chance to present a Presale. The reason is because they are responsible, and if there is a solution as an American Director you must explore that solution.

It would be irresponsible to not explore a potential solution.

Then it’s a simple case to actually give value in the presale meeting and convince them that we can deliver some thing that will benefit their business and profits.

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Total votes 6: ↑0 and ↓6 -6
Comments 2